Source Language (Chinese)
[摘要]目的：比较含烟酰胺和N-乙酰葡萄糖胺的护肤品双盲、基质对照人体试验。采用REAL3.0系统采集所有图像，用相关软件分析色斑面积百分比；NC2黑素图像色斑面积百分比、黑素均匀度、灰度；Chromameter测量非色斑部位皮肤颜色改变；专业皮肤科医生分析前后照片改善情况以及受试者主观评价。结果：与基质相比，含烟酰胺和N-乙酰葡萄糖胺的护肤品可以抑制色斑面积的增加，减轻紫外线引起的肤色加深和肤色不均匀。结论：正常人皮肤对含烟酰胺和N-乙酰葡萄糖胺的护肤品有良好的耐受性，与基质相比，这种护肤品有一定的改善色素沉着的效果。
[关键词] 烟酰胺；N-乙酰葡萄糖胺；色素沉着

Target Language (English)
[Abstract] Objective: The purpose of this study is to verify the depigmented role of regimen containing niacinamide and N-acetylglucosamine (N/NAG) on facial hyperpigmentation. Methods: This study was a vehicle-controlled, full-face, parallel group comparison in Chinese female subjects with facial hyperpigmentation. All pictures were taken by REAL 3.0 system. Spot area fraction, L*a*b, NC2 melanin spot area fraction, NC2 melanin gray scale and NC2 melanin evenness were analyzed by this system. A Chromameter was used to measure the L*a*b value for non-lesion area. Expert assessment on color pictures before and after the usage and self assessment questionnaires were also used. Results: Against the vehicle control, the N/NAG regimen provided significant benefits on reducing spot area fraction, minimized skin darkening and yellowing, increased skin tone evenness and minimized the NC2 melanin gray scale. Conclusions: The N/NAG regimen was well tolerated. Against the vehicle control, it produced a significant improvement in skin color and hyperpigmentation.